Buy Amaryl Online

What is Amaryl?

Amaryl (glimepiride) is an oral diabetes medicine that helps control blood sugar levels. This medication helps your body respond better to insulin produced by your pancreas.

Amaryl is used together with diet and exercise to treat type 2 diabetes. Insulin or other diabetes medicines are sometimes used in combination with this medicine if needed.

Amaryl may also be used for purposes not listed in this medication guide.

Important information about Amaryl

Do not use Amaryl if you are allergic to glimepiride, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Before taking Amaryl, tell your doctor if you are allergic to sulfa drugs, or if you have heart disease, liver disease, kidney disease, an enzyme deficiency (G6PD), adrenal or pituitary gland problems, or if you are under-nourished.

Take care not to let your blood sugar get too low. Low blood sugar (hypoglycemia) can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency.

Amaryl is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

Before taking Amaryl

You should not use Amaryl if you are allergic to glimepiride or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

To make sure you can safely take Amaryl, tell your doctor if you have any of these other conditions:

  • heart disease;
  • liver or kidney disease;
  • an allergy to sulfa drugs;

  • an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);

  • adrenal or pituitary gland problems; or

  • if you are under-nourished.

FDA pregnancy category C. It is not known whether Amaryl will harm an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Tell your doctor if you are pregnant or plan to become pregnant while using Amaryl. It is not known whether glimepiride passes into breast milk or if it could harm a nursing baby. Do not use Amaryl without telling your doctor if you are breast-feeding a baby.

How should I take Amaryl?

Take Amaryl exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Amaryl is usually taken once a day with breakfast or the first main meal of the day. Follow your doctor's instructions. Take Amaryl with a full glass of water. Know the signs of low blood sugar (hypoglycemia) and how to recognize them: headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating.

Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.

Your dose needs may change if you are ill, if you have a fever or infection, or if you have surgery or a medical emergency.

Ask your doctor how to adjust your Amaryl dose if needed. Do not change your medication dose or schedule without your doctor's advice.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Visit your doctor regularly.

Amaryl is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

Store Amaryl at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Use Amaryl regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, confusion, tremors, sweating, trouble speaking, blurred vision, nausea, fainting, and seizure (convulsions).

What should I avoid while taking Amaryl?

Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment. Avoid exposure to sunlight or tanning beds. Amaryl can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Amaryl side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Amaryl: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects while taking Amaryl:

  • severe skin rash, itching, redness, or irritation;

  • pale skin, easy bruising or bleeding, fever, unusual weakness;

  • numbness or tingly feeling;

  • trouble breathing;

  • feeling like you might pass out;

  • dark urine, clay-colored stools;

  • upper stomach pain, low fever, jaundice (yellowing of the skin or eyes); or

  • nausea, vomiting, loss of appetite, feeling restless or irritable, confusion, hallucinations, muscle pain or weakness, and/or seizure.

Less serious Amaryl side effects may include:

  • dizziness, headache, tired feeling;

  • mild nausea, vomiting, stomach pain, diarrhea;

  • increased skin sensitivity to sunlight; or

  • mild itching or skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Amaryl?

Using certain medicines can make it harder for you to tell when you have low blood sugar. Tell your doctor if you use any of the following:

  • albuterol (Proventil, Ventolin);

  • clonidine (Catapres);

  • reserpine;

  • a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others.

You may be more likely to have hypoglycemia (low blood sugar) if you take Amaryl with:

  • clarithromycin (Biaxin);

  • disopyramide (Norpace);

  • exenatide (Byetta);

  • fluoxetine (Prozac, Sarafem);

  • probenecid (Benemid);

  • an antibiotic such as ciprofloxacin (Cipro), ofloxacin (Floxin), norfloxacin (Noroxin), levofloxacin (Levaquin), and others;

  • some nonsteroidal anti-inflammatory drugs (NSAIDs);

  • aspirin or other salicylates (including Pepto-Bismol);

  • a blood thinner (warfarin, Coumadin and others);
  • a monoamine oxidase inhibitor (MAOI);

  • sulfa drugs (Bactrim, Gantanol, Septra, and others); or

  • other oral diabetes medications, especially acarbose (Precose), metformin (Glucophage), miglitol (Glyset), pioglitazone (Actos), or rosiglitazone (Avandia).

You may be more likely to have hyperglycemia (high blood sugar) if you take Amaryl with:

  • isoniazid;

  • diuretics (water pills);

  • steroids (prednisone and others);

  • niacin (Advicor, Niaspan, Niacor, Niaspan, Simcor, Slo-Niacin, and others);

  • phenothiazines (Compazine and others);

  • thyroid medicine (Synthroid and others);

  • birth control pills and other hormones;

  • seizure medicines (Dilantin and others);

  • diet pills; and

  • medicines to treat asthma, colds or allergies.

These lists are not complete and there are many other medicines that can increase or decrease the effects of Amaryl on lowering your blood sugar. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

For the Consumer

Applies to glimepiride: oral tablet

Along with its needed effects, glimepiride (the active ingredient contained in Amaryl) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking glimepiride:

Rare
  • Difficulty with swallowing
  • dizziness
  • fast heartbeat
  • hives
  • itching
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • shortness of breath
  • skin rash
  • tightness in the chest
  • unusual tiredness or weakness
  • wheezing
Incidence not known
  • Abdominal or stomach pain
  • agitation
  • back, leg, or stomach pains
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • bloating of abdomen
  • blood in the urine or stools
  • bloody, black, or tarry stools
  • chest pain
  • chills
  • coma
  • confusion
  • cough or hoarseness
  • dark urine
  • decreased urine output
  • depression
  • diarrhea
  • difficulty with breathing
  • fever with or without chills
  • fluid-filled skin blisters
  • general body swelling
  • general tiredness and weakness
  • headache
  • high fever
  • hostility
  • irritability
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lethargy
  • light-colored stools
  • loss of appetite
  • lower back or side pain
  • muscle twitching
  • nausea and vomiting
  • nosebleeds
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • red, irritated eyes
  • red skin lesions, often with a purple center
  • seizures
  • sensitivity to the sun
  • skin thinness
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stupor
  • swelling of face, ankles, or hands
  • swollen or painful glands
  • unusual bleeding or bruising
  • upper right abdominal or stomach pain
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking glimepiride:

Symptoms of overdose
  • Anxiety
  • blurred vision
  • cold sweats
  • cool, pale skin
  • increased hunger
  • nightmares
  • shakiness
  • slurred speech

Some side effects of glimepiride may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Lack or loss of strength
Incidence not known
  • Redness or other discoloration of the skin
  • severe sunburn

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Applies to glimepiride: oral tablet

Cardiovascular

The administration of oral hypoglycemic drugs has been associated with increased cardiovascular mortality as compared to treatment with diet alone or diet plus insulin. This warning is based on a study of 823 patients, which reported that patients treated for 5 to 8 years with diet plus a fixed dose of tolbutamide (1.5 G per day) had a rate of cardiovascular mortality approximately 2.5 times that of patients treated with diet alone. Although only one drug in the sulfonylurea class (tolbutamide) was included in this study, this warning may also apply to other drugs in this class in view of their close similarities in mode of action and chemical structure.

Cardiovascular side effects have included reports of increased mortality with some sulfonylurea agents, however, no such data exists for glimepiride.

Metabolic

Metabolic side effects have included hypoglycemia (blood sugars less than 60 mg/dl) in 0.9% to 1.7%. Hyponatremia occurred rarely. The syndrome of inappropriate antidiuretic hormone (SIADH) secretion, hepatic porphyria reactions, and disulfiram reactions have also been reported.

Nervous system

Nervous system side effects have included dizziness (1.7%), asthenia (1.6%), and headache (1.5%).

Ocular

Ocular side effects have included blurred vision and loss of accommodation in less than 1% of treated patients.

Dermatologic

Dermatologic side effects have included pruritus, erythema, urticaria, and morbilliform or maculopapular rashes in less than 1% of cases. Sulfonylureas have caused porphyria cutanea tarda and photosensitivity reactions.

Gastrointestinal

Gastrointestinal side effects have included nausea (1.1%). Vomiting, diarrhea, and pain were noted in less than 1% of cases.

Hematologic

Hematologic side effects have included leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia, and pancytopenia. Postmarketing reports include severe cases of thrombocytopenia with platelet count less than 10,000/uL and thrombocytopenic purpura.

Hepatic

Hepatic side effects have included cholestatic jaundice with other sulfonylureas. However, no data exists for glimepiride (the active ingredient contained in Amaryl)

Hypersensitivity

Hypersensitivity side effects have included allergic skin reactions, e.g., pruritus, erythema, urticaria, and morbilliform or maculopapular eruptions, which occurred in less than 1% of treated patients. Some of these were transient and disappeared despite continued use of glimepiride (the active ingredient contained in Amaryl) Allergic vasculitis has also been reported. Additional reports included hypersensitivity reactions worsening: such as dyspnea, fall in blood pressure, and shock.